Introduction: Most pain physicians know that fluoroscopy might improve the safety, accuracy, and efficacy of nerve block; however, it is difficult to distinguish the previously administered contrast medium from the injecting contrast medium, and to identify accurate contrast medium diffusion flow in a case of existing radiodensities such as cement and screw. Digital subtraction angiography (DSA) can improve accuracy of nerve blocks.Case Presentation: We described our experiences with two successful transforaminal epidural injections and nerve block of two patients with 73 and 68 years of age who were diagnosed as failed back surgery syndrome.Conclusions: The advantages of DSA in fluoroscopy-guided transforaminal epidural block and nerve block are identification of the degree of appropriate contrast flow (epidural and nerve root sleeve) and the intravascular administration without overlapping radiodense structures.